期刊
SCIENCE
卷 315, 期 5811, 页码 482-486出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1133542
关键词
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资金
- NICHD NIH HHS [T32: HD07466] Funding Source: Medline
Genetically matched pluripotent embryonic stem (ES) cells generated via nuclear transfer or parthenogenesis (pES cells) are a potential source of histocompatible cells and tissues for transplantation. After parthenogenetic activation of murine oocytes and interruption of meiosis I or II, we isolated and genotyped pES cells and characterized those that carried the full complement of major histocompatibility complex (MHC) antigens of the oocyte donor. Differentiated tissues from these pES cells engrafted in immunocompetent MHC-matched mouse recipients, demonstrating that selected pES cells can serve as a source of histocompatible tissues for transplantation.
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