期刊
BRITISH JOURNAL OF CANCER
卷 96, 期 2, 页码 183-188出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.bjc.6603516
关键词
oncogenic virus; epigenetics; methylation; histone modifications; p300; CBP; KSHV; HHV8
类别
Epigenetic alterations represent an important step in the initiation and progression of most human cancers, but it is difficult to differentiate the early cancer causing alterations from later consequences. Oncogenic viruses can induce transformation via expression of only a small number of viral genes. Therefore, the mechanisms by which oncogenic viruses cause cancer may provide clues as to which epigenetic alterations are critical in early carcinogenesis.
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