期刊
PRENATAL DIAGNOSIS
卷 27, 期 2, 页码 119-123出版社
WILEY
DOI: 10.1002/pd.1617
关键词
nuchal translucency; prenatal diagnosis; down syndrome; prenatal screening
资金
- NICHD NIH HHS [HD01262] Funding Source: Medline
Objective To examine how women use the nuchal translucency (NT) risk adjustment in decision-making for invasive prenatal diagnosis. Study Design Retrospective cohort study of 1083 consecutive NT screening exams. A screen-positive test was defined as a risk >= 1/300. Primary outcome was what proportion of screen-positive or screen-negative women chose to undergo chorionic villus sampling or amniocentesis. Results Of the women tested, 79% (858/1083) were >= 35-years-old and 88% (756/858) of these women had a decrease in age-related risk after NT. Of the screen-negative women, 31% (238/756) >= 35 years of age chose to have invasive testing as compared to only 11.2% (25/223) of those <35 years of age (p < 0.001). Of the screen-positive women, 71% (72/102) >= 35 years of age and 100% (2/2) <35 years of age chose to obtain invasive testing (p = 0.368). Conclusion First-trimester NT screening for Down syndrome (DS) enables a significant number of women over age 35 to lower the risk for DS several fold and avoid the risks of invasive testing. However, despite significant reductions in age-specific mid-trimester DS risks, a relatively high proportion of women >= 35 years of age still opted for invasive testing. Copyright (C) 2006 John Wiley & Sons, Ltd.
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