期刊
JOURNAL OF VIROLOGY
卷 81, 期 3, 页码 1517-1523出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.01780-06
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资金
- NCRR NIH HHS [C06 RR020141, C06 RR015459, RR020141-01, R24 RR015371, RR15459-01, P51 RR000167] Funding Source: Medline
- NIAID NIH HHS [R01 AI049120, R01 AI052056] Funding Source: Medline
Current assays of CD8(+) T-lymphocyte function measure cytokine production rather than the ability of these lymphocytes to suppress viral replication. Here we show that CD8(+) T-cell clones recognizing the same epitope vary enormously in the ability to suppress simian immunodeficiency virus SIVmac239 replication in an in vitro suppression assay. However, all Nef(165-173)IW9- and Vif(66-73)HW8-specific clones from elite controllers effectively suppressed SIV replication. Interestingly, in vitro suppression efficacy was not always associated with the ability to produce gamma interferon, tumor necrosis factor alpha, or interleukin-2.
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