期刊
MICROBIAL PATHOGENESIS
卷 42, 期 2-3, 页码 94-97出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.micpath.2006.09.001
关键词
Staphylococcus epidermidis; biofilm; PIA; ica operon; pathogenesis; tissue cage infection model
The pathogenesis of Staphylococcus epidermidis is thought to be based on its capacity to colonize medical devices by forming a biofilm. Biofilm formation is in part mediated by the polysaccharide intercellular adhesin (PIA), which is encoded by the icaADBC operon. We have previously investigated in vitro the correlation existing between biofilm formation (B +/-), presence of ica locus (1 +/-) and PTA production (P +/-) in some clinical isolates of coagulase-negative staphylococci (CoNS). Here, we used a guinea pig model of subcutaneous implanted tissue cages to assess the implication of 13 I and P parameters in the capacity of nine S. epidermidis and one S. carnosus strains to develop and maintain an infection in vivo. Using clinical isolates and a model strain of S. epidermidis, we showed that the B+, I+, P+ type confers the ability to maintain an infection in vivo. Surprisingly, the opposite type B-, I-, P- tested with clinical and commensal isolates, presented infection rates ranging from 25% to 60%. Other clinical isolates having a B+ I+, P- type, were not able to cause an infection in the present model. These results showed that, depending on the strains the capacity to colonize the tissue cage might be independent of the ability to form biofilm. (c) 2006 Elsevier Ltd. All rights reserved.
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