期刊
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
卷 74, 期 2, 页码 282-289出版社
SPRINGER
DOI: 10.1007/s00253-006-0763-1
关键词
thymine; biosynthesis; flavin; thymidylate synthase
资金
- NIGMS NIH HHS [R01 GM65368-01] Funding Source: Medline
The two long- known classical enzymes of uridyl-5-methylation, thymidylate synthase and ribothymidyl synthase, have been joined by two alternative methylation enzymes, flavin-dependent thymidylate synthase and folate-dependent ribothymidyl synthase. These two newly discovered enzymes have much in common: both contain flavin cofactors, utilize methylenetetrahydrofolate as a source of methyl group, and perform thymidylate synthesis via chemical pathways distinct from those of their classic counterparts. Several severe human pathogens (e.g., typhus, anthrax, tuberculosis, and more) depend on these alternative enzymes for reproduction. These and other distinctive properties make the alternative enzymes and their corresponding genes appealing targets for new antibiotics.
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