期刊
CELLULAR AND MOLECULAR NEUROBIOLOGY
卷 27, 期 2, 页码 171-177出版社
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10571-006-9082-4
关键词
primary cell culture; glutamate; melatonin; riluzole; 7-nitroindazole
1. Glial cells are the most abundant cell population in the central nervous system. The aim of this study was to examine the effects of melatonin, 7-nitroindazole, and riluzole on glutamate toxicity in primary glial cell culture. 2. Glutamate toxicity was induced by addition of 100 mu M glutamate to the cultures, and then 100 mu M melatonin, 500 mu M 7-nitroindazole, and 10 (M riluzole were administered in different groups. Lactate Dehydrogenase activity and nitrite levels were determined at the 1st, 6th, and 24th h. 3. Melatonin, 7-nitroindazole, and riluzole decrease Lactate Dehydrogenase activity at the 1st, 6th, and 24th h (at all hours, p < 0.05). Nitrite levels were decreased by melatonin and riluzole at the 1st, 6th, and 24th h. 4. In this study, we observed that melatonin, 7-nitroindazole, and riluzole are effective as protective agents on glutamate toxicity in mixed glial cells.
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