期刊
BIOLOGICAL PSYCHIATRY
卷 61, 期 3, 页码 412-414出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.biopsych.2006.12.014
关键词
obsessive compulsive disorder; quetiapine; serotonin reuptake inhibitor
Background. The purpose of this study was to assess the effect of type and dose of serotonin reuptake inhibitors (SRIs) on treatment outcome in quetiapine addition trials for obsessive-compulsive disorder. Methods. Results from all available, double blind, placebo-controlled quetiapine addition trials were pooled. Treatment outcome was assessed in a sample of 102 patients by change from baseline to end point on the Yale-Brown obsessive-compulsive scale (Y-BOCS). Results. Quetiapine addition was superior with a mean Y-BOCS decrease of 6.8 +/- 6 7 compared with placebo with a decrease of3.9 +/- 6.5 points. Patients with the lowest SRI dose showed the largest decrease on the Y-BOCS (11 6 +/- 7.7) compared with patients with the median dose (6.1 +/- 6.1) and highest dose (5.9 +/- 6 4). Conclusions: We found a superior response in the quetiapine addition group compared with the placebo group. The best response was achieved with the combination of clomipramine, fluoxetine, and fluvoxamine and with the lowest SRI doses.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据