期刊
CURRENT OPINION IN CHEMICAL BIOLOGY
卷 11, 期 1, 页码 74-82出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.cbpa.2006.11.031
关键词
-
资金
- NCI NIH HHS [N01-CO-12400] Funding Source: Medline
Uncovering the functions of thousands of gene products, in various states of post-translational modification, is a key challenge in the post-genome era. To identify small-molecule probes for each protein function, high-throughput methods for ligand discovery are needed. In recent years, small-molecule microarrays (SMMs) have emerged as high-throughput and miniaturized screening tools for discovering protein-small-molecule interactions. Microarrays of small molecules from a variety of sources, including FDA-approved drugs, natural products and products of combinatorial chemistry and diversity-oriented synthesis, have been prepared and screened by several laboratories, leading to several newly discovered protein-ligand pairs.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据