期刊
ULTRASOUND IN MEDICINE AND BIOLOGY
卷 33, 期 2, 页码 263-269出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.ultrasmedbio.2006.07.039
关键词
acoustic radiation force; laser-induced optical breakdown; microbubble; chirp; standing waves
资金
- NEI NIH HHS [R21 EY015876, EY 015876] Funding Source: Medline
- NIBIB NIH HHS [R21 EB003449] Funding Source: Medline
Bubble-based acoustic radiation force can measure local viscoelastic properties of tissue. High intensity acoustic waves applied to laser-generated bubbles induce displacements inversely proportional to local Young's modulus. In certain instances, long pulse durations are desirable but are susceptible to standing wave artifacts, which corrupt displacement measurements. Chirp pulse acoustic radiation force was investigated as a method to reduce standing wave artifacts. Chirp pulses with linear frequency sweep magnitudes of 100, 200 and 300 kHz centered around 1.5 MHz were applied to glass beads within gelatin phantoms and laser-generated bubbles within porcine lenses. The ultrasound transducer was translated axially to vary standing wave conditions, while comparing displacements using chirp pulses and 1.5 MHz tone burst pulses of the same duration and peak rarefactional pressure. Results demonstrated significant reduction in standing wave effects using chirp pulses, with displacement proportional to acoustic intensity and bubble size.
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