期刊
EUKARYOTIC CELL
卷 6, 期 2, 页码 346-350出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/EC.00336-06
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资金
- NHLBI NIH HHS [R01HL0636] Funding Source: Medline
- NIAID NIH HHS [R01 AI059201, 1R01AI059201] Funding Source: Medline
Many single-celled eukaryotes produce prostaglandin-like molecules, but these have not been absolutely verified by mass spectrometry. We have isolated, and identified by liquid chromatography-tandem mass spectrometry, authentic prostaglandin E-2 from Cryptococcus neoformans. Cyclooxygenase inhibitors did not inhibit prostaglandin synthesis, and the cryptococcal genome lacks a cyclooxygenase homolog. Thus, novel enzymes must exist.
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