期刊
CLINICA CHIMICA ACTA
卷 377, 期 1-2, 页码 62-69出版社
ELSEVIER
DOI: 10.1016/j.cca.2006.10.017
关键词
von Willebrand factor; von Willebrand disease; acquired von Willebrand syndrome; bleeding
von Willebrand factor is a multimeric plasma protein that mediates platelet adhesion as well as platelet aggregation at sites of vascular injury and, moreover, acts as a carrier of factor VIII. Its deficiency is associated with a bleeding tendency. The progresses in the pathophysiology, diagnosis and management of inherited von Willebrand disease and acquired von Willebrand syndrome will be discussed in this review. (c) 2006 Elsevier B.V. All rights reserved.
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