期刊
CURRENT OPINION IN NEUROBIOLOGY
卷 17, 期 1, 页码 103-111出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.conb.2007.01.009
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资金
- NICHD NIH HHS [HD15052] Funding Source: Medline
- NIMH NIH HHS [R01 MH64547, MH65299, U54 MH68172] Funding Source: Medline
Autism is a common and heterogeneous childhood neurodevelopmental disorder. Analogous to broad syndromes such as mental retardation, autism has many etiologies and should be considered not as a single disorder but, rather, as 'the autisms'. However, recent genetic findings, coupled with emerging anatomical and functional imaging studies, suggest a potential unifying model in which higher-order association areas of the brain that normally connect to the frontal lobe are partially disconnected during development. This concept of developmental disconnection can accommodate the specific neurobehavioral features that are observed in autism, their emergence during development, and the heterogeneity of autism etiology, behaviors and cognition.
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