期刊
HAEMATOLOGICA
卷 92, 期 2, 页码 283-284出版社
FERRATA STORTI FOUNDATION
DOI: 10.3324/haematol.10667
关键词
immune thrombocytopenia; platelet autoantibody specificity; intravenous immunoglobulin
类别
资金
- Gundersen Lutheran Center for Cancer and Blood Disorders
- Gundersen Lutheran Medical Foundation
We retrospectively investigated the association between platelet autoantibody specificity and response to intravenous immunoglobulin G (IVIG) in 17 patients with immune thrombocytopenia (ITP). Platelet-associated antibodies against glycoprotein (GP) IIb/IIIa, GPIb/IX, and GPIa/IIa were detected in 13, 10, and 8 patients, respectively. A response occurred in 7 of 7 patients without anti-GPIb/IX, but in only 3 of 10 patients with anti-GPIb/IX (p<0.01). There was no difference in the response rates in patients with or without anti-GPIIb/IIIa or anti-GPIa/IIa. We conclude that ITP patients with anti-GPIb/IX may be less responsive to IVIG.
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