期刊
NEUROCHEMICAL RESEARCH
卷 32, 期 2, 页码 257-262出版社
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s11064-006-9145-4
关键词
myelin; sulfatide; central nervous system; demyelination; CD1; glycolipids; microglia; multiple sclerosis; EAE
Here we briefly review our understanding of the immune response to myelin-derived glycolipids during an inflammatory autoimmune response in the central nervous system (CNS). We focus primarily on the recognition of the self-glycolipid sulfatide by a distinct population of non-invariant NK T cells. The results of studies we have obtained so far in investigating the presentation of sulfatide by CNS-resident cells including microglia and their interactions with T cells indicate that this pathway might be successfully targeted for the treatment of autoimmune demyelination in multiple sclerosis.
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