期刊
NATURE CLINICAL PRACTICE NEUROLOGY
卷 3, 期 2, 页码 107-112出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ncpneuro0373
关键词
ataxia; dementia; neuropathy; parkinsonism; tremor
资金
- NIA NIH HHS [AG024488] Funding Source: Medline
- NICHD NIH HHS [HD02274, HD36071] Funding Source: Medline
- NINDS NIH HHS [NS43532] Funding Source: Medline
- PHS HHS [U10/CCU 92513] Funding Source: Medline
Background A 76-year-old man presented with an 8-year history of balance problems and a 2-year history of short-term memory loss. He had also been experiencing long-term problems with impotence and episodes of urinary incontinence, and had been managed for hypertension for 25 years. His medical history was otherwise unremarkable. Three of his grandchildren had been diagnosed with fragile X syndrome. Investigations Neurological examination, cognitive and neuropsychological testing, nerve conduction studies, MRI, and genetic testing. Diagnosis Fragile X-associated tremor/ataxia syndrome ( FXTAS) resulting from a premutation ( CGG repeat) expansion of the FMR1 gene. Management Explanation of the genetic ramifications of premutation carrier status for the FMR1 gene, and symptomatic treatment for the clinical difficulties experienced by the patient.
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