期刊
MITOCHONDRION
卷 7, 期 1-2, 页码 53-57出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.mito.2006.12.001
关键词
mitochondrial DNA; cancer; cancer progression
资金
- NCI NIH HHS [R01 CA100846-03, CA100846, R01 CA100846-02, R01 CA100846-01A1, R01 CA100846, R01 CA100846-04] Funding Source: Medline
Enzymatic activities of the proteins encoded in nuclear genome are regulated by transcriptional, translational and post-transcriptional level. Enzymatic. activities of proteins encoded in mitochondrial DNA (mtDNA) have been considered to be regulated by the same steps although detailed mechanisms might differ. However, dynamic change of the number of mtDNA, from some hundred to more than ten thousand, should be considered as another novel mechanism to regulate mtDNA-encoded proteins. Recently, we showed the connection of mtDNA depletion and deletion to cancer progression [Higuchi, M., Kudo, T., Suzuki, S., Evans, T.T., Sasaki, R., Wada, Y., Shirakawa, T., Sawyer, J.R., Gotoh, A., 2006. Mitochondrial DNA determines androgen dependence in prostate cancer cell lines. Oncogene 25, 1437-1445]. This review focuses and describes the possible connections of the mitochondrial DNA depletion and deletion to cancer. (c) 2007 Elsevier B.V. and Mitochondria Research Society. All rights reserved.
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