期刊
CONTEMPORARY CLINICAL TRIALS
卷 28, 期 2, 页码 182-191出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cct.2006.05.007
关键词
cluster randomized trial; stepped wedge design; prevention trials
资金
- NIAID NIH HHS [AI46702, AI29168] Funding Source: Medline
Cluster randomized trials (CRT) are often used to evaluate therapies or interventions in situations where individual randomization is not possible or not desirable for logistic, financial or ethical reasons. While a significant and rapidly growing body of literature exists on CRTs utilizing a parallel design (i.e. I clusters randomized to each treatment), only a few examples of CRTs using crossover designs have been described. In this article we discuss the design and analysis of a particular type of crossover CRT - the stepped wedge - and provide an example of its use. (c) 2006 Elsevier Inc. All rights reserved.
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