期刊
JOURNAL OF PHARMACOLOGICAL SCIENCES
卷 103, 期 2, 页码 247-251出版社
JAPANESE PHARMACOLOGICAL SOC
DOI: 10.1254/jphs.SC0060148
关键词
iberin; glioblastoma; apoptosis
In this study, we evaluated the antiproliferative and proapoptotic effects of the isothiocyanate iberin, a bioactive agent in Brassicaceae species, in human glioblastoma cells. The human glioblastoma cell cultures were treated with different concentrations of iberin and tested for growth inhibition, cytotoxicity, induction of apoptosis, and activation of caspases. Iberin inhibited growth of tumor cells in cell proliferation assays, enhanced cytotoxicity, and induced apoptosis by activation of caspase-3 and caspase-9. Findings from this study could provide a basis for potential usefulness of the diet-derived isothlocyanate iberin as a promising therapeutic micronutrient in the prevention / intervention of brain tumors.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据