期刊
JOURNAL OF BONE AND MINERAL RESEARCH
卷 22, 期 2, 页码 318-328出版社
AMER SOC BONE & MINERAL RES
DOI: 10.1359/JBMR.061104
关键词
chondrocyte; mechanotransduction; matrilin; pericellular matrix; hedgehog
资金
- NIGMS NIH HHS [P20 GM104937] Funding Source: Medline
Pericellular matrix is at the ideal location to be involved in transmitting mechanical signals from the microenvironment to a cell. We found that changes of the content of matrilins that link various pericellular molecules surrounding chondrocytes affect mechanical stimulation of chondrocyte proliferation and gene expression. Thus, pericellular matrilins may play a role in chondrocyte mechanotransduction.
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