期刊
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
卷 1770, 期 2, 页码 171-177出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbagen.2006.09.026
关键词
urinary trypsin inhibitor; glycosaminoglycan; chondroitin sulfate
Five isomers with different electric charge were fractionated from human urinary trypsin inhibitor (UTI) by anion exchange HPLC. Intact low-sulfated chondroitin 4-sulfate chains from the isomers were analyzed by HPLC and mass spectrometry. Unsaturated disaccharide composition analysis of the chondroitin sulfate chain revealed that the five isomers differ in the numbers of 4-sulfated disaccharide units. Intriguingly, we detected the presence of multiple novel isomers with different numbers of non-sulfated disaccharide units even in the same charge isomer fraction. Our results demonstrate that UTI can vary in terms of both the degree Of sulfation and the length of the low-sulfated chondroitin 4-sulfate chain. (c) 2006 Elsevier B.V. All rights reserved.
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