期刊
MOLECULAR AND CELLULAR NEUROSCIENCE
卷 34, 期 2, 页码 219-230出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.mcn.2006.11.001
关键词
GluR5; GluR6 and KA2; kainate receptors; proximal and distal dendrites; microtubule motor protein; KIF17 motor proteins; cultured hippocampal neurons; kainate receptor knock-out mice; receptor trafficking; subunit composition
资金
- NINDS NIH HHS [R01 NS028709-10] Funding Source: Medline
Correct glutamate receptor localization in neurons is crucial for neurotransmission in the brain. Here we investigated the mechanisms underlying localization of kainate GluR5 receptors to dendrites in cultured hippocampal neurons. We find that the GluR5 distribution depends on association with GluR6 and KA2 subunits. The GluR5 subunit was expressed in distal dendrites only when GluR6 and KA2 subunits were present, whereas it was restricted to proximal dendrites in the absence of these subunits. The overlap between GluR5 distribution and the organization of microtubules in dendrites led us to examine whether KIF17, a microtubule motor protein expressed in distal dendrites, is involved in GluR5 localization to distal dendrites. We show here, for the first time that the microtubule motor protein KIF17 interacts with GluR6 and KA2 subunits and is required for GluR5 localization to distal dendrites, defining a novel mechanism that controls receptor localization in neurons. (c) 2006 Elsevier Inc. All rights reserved.
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