期刊
RESEARCH IN VETERINARY SCIENCE
卷 82, 期 1, 页码 39-46出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.rvsc.2006.05.006
关键词
endotoxin; inflammation; lipopolysaccharide; mastitis; Staphylococcus aureus; toll-like receptor
Mastitis due to Staphylococeus aureus is a significant problem in the dairy industry and is refractory to antibiotic treatment and/or vaccine prevention. Relative to other mastitis-causing pathogens, S. aureus elicits a diminutive host inflammatory response during intra-mammary infection. To determine whether induction of a heightened inflammatory response could influence outcome of infection, the highly pro-inflammatory molecule bacterial lipopolysaccharide (LPS) was infused into udder quarters experimentally infected with S. aureus. Relative to S. aureus-infected udder quarters receiving saline, quarters infused with LPS demonstrated a heightened inflammatory response as demonstrated by the induction of TNF-alpha and higher milk somatic cell counts and albumin levels. Although there was no overall effect on bacterial clearance, a trend toward reduced bacterial numbers during the immediate pro-inflammatory response following LPS infusion was observed suggesting that this novel approach to treating S. aureus intramammary infection may warrant further investigation. Published by Elsevier Ltd.
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