期刊
CURRENT DIRECTIONS IN PSYCHOLOGICAL SCIENCE
卷 16, 期 1, 页码 37-41出版社
SAGE PUBLICATIONS INC
DOI: 10.1111/j.1467-8721.2007.00471.x
关键词
anorexia nervosa; bulimia nervosa; genetic; gene
资金
- NIMH NIH HHS [T32 MH070343-01, T32 MH070343] Funding Source: Medline
We review association studies that have examined the genetic basis of eating disorders. Overall, findings suggest that serotonin, brain-derived neurotrophic factor, and estrogen genes may be important for the development of the disorders. These neuronal systems influence behavioral and personality characteristics (e.g., anxiety, food intake) that are disrupted in eating disorders. Future studies would benefit from larger sample sizes and inclusion of behavioral and personality covariates in analyses. Consideration of the mechanisms of genetic effects and interactions between genes and environment is also needed to extend conceptualizations of the genetic basis of these disorders.
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