期刊
PLOS GENETICS
卷 3, 期 2, 页码 161-173出版社
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pgen.0030024
关键词
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资金
- NIA NIH HHS [T32 AG000213, AG021905, T32 AG00213, R01 AG021905] Funding Source: Medline
Mitochondrial DNA (mtDNA) accumulates both base-substitution mutations and deletions with aging in several tissues in mammals. Here, we examine the evidence supporting a causative role for mtDNA mutations in mammalian aging. We describe and compare human diseases and mouse models associated with mitochondrial genome instability. We also discuss potential mechanisms for the generation of these mutations and the means by which they may mediate their pathological consequences. Strategies for slowing the accumulation and attenuating the effects of mtDNA mutations are discussed.
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