期刊
CURRENT OPINION IN PHARMACOLOGY
卷 7, 期 1, 页码 48-55出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.coph.2006.08.013
关键词
-
资金
- NIMH NIH HHS [MH53327, MH70895] Funding Source: Medline
The pathophysiology of schizophrenia is poorly understood but is likely to involve alterations in excitatory glutamatergic signaling molecules in several areas of the brain. Clinical and experimental evidence has shown that expression of the N-methyl-D-asparate (NMDA) receptor and intracellular NMDA receptor-interacting proteins of the glutaminergic synapse appear to be dysregulated in schizophrenia. It has been suggested that schizophrenia involves molecular changes in the glutamatergic pathways that mediate excitatory communication between multiple brain regions. Recent data also implicate abnormalities in cellular functions such as receptor trafficking and synaptic targeting.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据