期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 183, 期 1-2, 页码 60-68出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2006.11.009
关键词
copolymer-1; MPTP; immunomodulation; neuroprotection; CD4(+) T cells; Parkinson's disease
资金
- NCRR NIH HHS [P20 RR15635] Funding Source: Medline
- NIMH NIH HHS [5 P01 MH64570-03] Funding Source: Medline
- NINDS NIH HHS [1T32 NS07488, 2R37 NS36126, 1R21 NS049264, 1 P01 NS043985-01] Funding Source: Medline
Adoptive transfer of lymphoid cells from Copolymer 1 (Cop-1) immunized mice leads to T cell accumulation within the substantia nigra, modulation of microglial responses, upregulation of glial cell derived neurotrophic factor, and protection of the nigrostriatum following 1-methyl-4-phenyl- 1,2,3,6-tetrahydropyridine (MPTP) intoxication. We now demonstrate that T cells isolated from lymph nodes and spleens of Cop-1 immunized animals protect the nigrostriatal system from MPTP-induced neurodegeneration in a dose-dependent manner. CD4+ T cells elicited the most significant neuroprotective response while high titers of anti-Cop-1 antibodies showed no effect. These data further support the use of immunomodulatory strategies for Parkinson's disease. (c) 2006 Published by Elsevier B.V.
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