期刊
JOURNAL OF CLINICAL PERIODONTOLOGY
卷 34, 期 2, 页码 118-123出版社
WILEY
DOI: 10.1111/j.1600-051X.2006.01032.x
关键词
diabetes; glycaemic control; HsCRP; lipid profile; periodontitis
AimL The aim of this study was to investigate the relationship between markers of metabolic control and inflammation and periodontal disease parameters in patients with diabetes. Material & Methos: One hundred and eighty one adult patients with diabetes attending treatment at two diabetes centres were invited to participate in the study. Periodontal examination included full-mouth assessment for probing depths and bleeding on probing (BOP). Blood analyses were carried out for glycated haemoglobin, (HbA1c), high-sensitivity C reactive protein, (hsCRP) and lipid profile comprising total cholesterol, low-density lipoprotein cholesterol (LDL chol), high-density lipoprotein cholesterol (HDL chol) and triglycerides. Results: Upon multivariate analysis, periodontal disease severity in terms of increased percentage of BOP and mean percentage of sites with probing depths >= 5 mm were found to be associated with inadequate glycaemic control as measured by HbA1c (p < 0.01). HsCRP was also found to be a significant predictor for mean percentage of sites with probing depths >= 5 mm (p < 0.05). After controlling for age, gender, smoking habits and number of teeth, positive correlations were found between HbA1c and percentage sites with probing depths >= 5 mm, percentage sites BOP, total cholesterol, LDL chol and triglycerides (p < 0.05). Using the adjusted differences, subjects with acceptable glycaemic control (HbA1c < 8%) showed a lower percentage of sites with BOP and probing depths >= 5 mm (p < 0.05) when compared with those having inadequate glycaemic control. There was also a trend towards lower blood cholesterol in the well-controlled group. Conclusion: The level of glycaemic control as measured by HbA1c emerged as the most consistent risk factor associated with the extent and severity of periodontal disease in this study cohort.
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