In(III)-mediated chemoselective dehydrogenative interaction of ClMe2SiH with carboxylic acids:: Direct chemo- and regioselective Friedel-Crafts acylation of aromatic ethers

Chemoselective dehydrogenative interaction of ClMe2SiH with a carboxylic acid group in the presence of InX3 is reported. C-13 NMR investigation revealed the formation of PhCOOSi(Cl)Me-2 as the major transient intermediate. Chemo- and regioselective Friedel-Crafts acylation of aromatic ethers directly from carboxylic acids was established.