期刊
JOURNAL OF PEDIATRICS
卷 150, 期 2, 页码 146-150出版社
MOSBY-ELSEVIER
DOI: 10.1016/j.jpeds.2006.10.054
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资金
- NCRR NIH HHS [K23RR020038-02] Funding Source: Medline
- NIDDK NIH HHS [P30 DK57516, T32 DK063687-03, K12 DK063722-03] Funding Source: Medline
Objective: Because cardiovascular disease (CVD) is the leading cause of death in patients with type 1 diabetes (T1D) and dyslipidemia is an important CVD risk factor, we investigated dyslipidemia and its treatment in children with T1D. Study design: Subjects had T1D (n = 360), repeated lipid measurements (n = 1095; mean, 3.04 +/- 0.94; range, 2 to 11), and were seen between 1994 and 2004. Total cholesterol (TC), high-density lipoprotein cholesterol (HDL), and non-HDL cholesterol (non-HDL) were categorized on the basis of published guidelines. Age, diabetes duration, sex, body mass index, HbA1c, and lipid-lowering medication use were recorded. Predictors of TC, HDL, and non-HDL were determined. Results: Sustained abnormalities existed for TC >= 200 mg/dL (16.9%); HDL < 35 mg/dL (3.3%); and non-HDL >= 130 mg/dL (27.8%), >= 160 mg/dL (10.6%), and >= 190 mg/dL (3.3%). Lipid-lowering medications were started on 23 patients. In mixed model longitudinal data analyses, HbA1c was significantly related to TC and non-HDL. Body mass index z-score was inversely related to HDL. Conclusions: In this retrospective, longitudinal study of pediatric patients with T1D with repeated lipid measurements, sustained abnormal levels for TC, HDL, and non-HDL were present. Prospective longitudinal data for dyshpidemia in youth with T1D are needed.
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