期刊
SEMINARS IN IMMUNOLOGY
卷 19, 期 1, 页码 3-10出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.smim.2006.12.002
关键词
toll-like receptor; innate immunity; lipopolysaccharide; lipopeptide; radioprotective 105
类别
The Toll family of receptors consists of cell surface TLRs (TLR4/MD-2, TLR1, TLR2, and TLR6) and intracellular TLRs (TLR3, TLR7, TLR8, and TLR9). Cell surface TLRs sense microbial membranes such as lipopolysaccharide or lipopeptides. Recognition by TLRs is the frontline where pathogens and a host try to take the control of immune responses. Bacteria can modulate the structure of a TLR ligand lipid A to subvert host responses. Cell surface TLRs also sense endogenous ligands which are released in tissue damages as danger signals and induce inflammation in infectious and non-infectious condition. The availability of endogenous ligands and the amount of cell surface TLRs are both tightly limited to keep TLR responses sufficient for containment of pathogens without detrimental responses to the host. (c) 2007 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据