Spectroscopic studies of some thiosemicarbazide compounds derived from Girard's T and P

Three new derivatives of thiosemicarbazides, derived from the reactions of ethyl-, allyl- and phenyl isothiocyanates with Girard's T [(carboxymethyl) trimethylammonium chloride hydrazide] and P [1-(carboxymethyl) pyridinium chloride hydrazide], have been isolated and characterized by chemical analyses, conductivities, spectral (IR, H-1 NMR) and molecular weight measurements. The most important assignments of the functional groups in the isolated solid organic compounds have been determined using IR spectra. Also, the main functional groups in the skeleton of these compounds have been characterized using H-1 NMR spectra. Moreover, a comparative studies between the three thiosemicarbazide derivatives have been carried out. The role of the existence of ethyl-, allyl-, phenyl-, [(CH3)(3)N+-] and [C5H5N+-] on the position of the functional groups has been investigated. Finally, the absence of any type of hydrogen bonding (inter- and/or intra-) within these compounds is discussed on the basis of the data of melting points, IR and H-1 NMR spectra and molecular weight measurements. (c) 2006 Elsevier B.V. All rights reserved.