期刊
MOLECULAR AND CELLULAR ENDOCRINOLOGY
卷 265, 期 -, 页码 126-130出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2006.12.008
关键词
glomerulosa cells; angiotensin II; actin; MAPK; rho-rac
Angiotensin II is one of the most important stimuli of rat adrenal glomerulosa cells, stimulating both steroid secretion and growth. In a previous report, we had shown that Ang II promotes cellular hypertrophy, but not proliferation, in rat adrenal glomerulosa cells maintained in primary culture for 3 days. The inhibition of proliferation and stimulation of hypertrophy induced by Ang II involves both p42/p44(mapk) and p38 MAPK activation. The increase in cell protein content induced by Ang II entails formation of a cortical actin ring and Rac-dependent activation of p42/p44(mapk) and p38 MAPK. The present study summarizes these results and provides evidences that Ang II-induced activation of p42/p44(mapk) and p38 MAPK are implicated in aldosterone secretion by enhancing expression of specific steroidogenic proteins such as StAR and 3 beta-HSD. (c) 2007 Elsevier Ireland Ltd. All rights reserved.
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