Derepression of excision of integrative and potentially conjugative elements from Streptococcus thermophilus by DNA damage response:: Implication of a cI-related repressor

A DNA-damaging agent, mitomycin C, derepresses the site-specific excision of two integrative and potentially conjugative elements from Streptococcus thermophilus, ICESt1 and ICESt3. The regulation pathway involves a repressor related to phage lambda cI repressor. It could also involve a putative regulator related to another type of phage repressors, the cI-like repressors.