期刊
NEUROBIOLOGY OF AGING
卷 28, 期 2, 页码 314-324出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2005.12.001
关键词
aging; agonal state; hsp70; heat shock genes; human brain; postmortem interval
资金
- NIA NIH HHS [P50 AG08013, P30 AG12300, AG12297] Funding Source: Medline
Differential expression of heat shock genes can modulate protein folding and stress-related cell death. There have been no comparisons of their levels of expression in animals and humans. Levels of expression of heat shock 70 genes in human brain were compared to levels in non-stressed and heat-stressed brain of rat. Levels of hsp70 proteins in human brain were 43-fold higher than in non-stressed rat brain and 14-fold higher than highest induced levels in brains of heat-shocked rats. Levels of constitutively synthesized hsc70 proteins were approximately 1.5-fold higher in human than in rat. Higher levels of hsp70 proteins in human brain may serve to protect brain cells against stress-related death or dysfunction throughout the lifespan. Published by Elsevier Inc.
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