期刊
ANGIOGENESIS
卷 22, 期 1, 页码 95-102出版社
SPRINGER
DOI: 10.1007/s10456-018-9640-7
关键词
Telomere; Dyskeratosis congenita; Consortium; Vascular biology
资金
- Intramural Research Program of the Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Dyskeratosis Congenita Outreach, Inc.
- Translational Research Program (Boston Children's Hospital)
- Dana-Farber/Boston Children's Cancer and Blood Disorders Center
- Texas Children's Cancer and Hematology Centers
- NATIONAL CANCER INSTITUTE [ZIDBC011317, ZIACP010190] Funding Source: NIH RePORTER
Vascular complications such as bleeding due to gastrointestinal telangiectatic anomalies, pulmonary arteriovenous malformations, hepatopulmonary syndrome, and retinal vessel abnormalities are being reported in patients with telomere biology disorders (TBDs) more frequently than previously described. The international clinical care consortium of telomere-associated ailments and family support group Dyskeratosis Congenita Outreach, Inc. held a workshop on vascular abnormalities in the TBDs at the National Cancer Institute in October 2017. Clinicians and basic scientists reviewed current data on vascular complications, hypotheses for the underlying biology and developed new collaborations to address the etiology and clinical management of vascular complications in TBDs.
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