期刊
JOURNAL OF POLYMER RESEARCH
卷 14, 期 1, 页码 53-59出版社
SPRINGER
DOI: 10.1007/s10965-006-9080-8
关键词
electrospinning; methacrylate-based copolymer; drug release; indomethacin
Three methacrylate-based copolymers [i.e., poly(methacrylic acid-co-methyl methacrylate) (E-L100), poly(ethyl acrylate-co-methyl methacrylate-co-trimethyl-ammonioethyl methacrylate chloride) (E-RLPO), and poly(butyl methacrylate-co-(2-dimethylaminoethyl) methacrylate-co-methyl methacrylate) (E-EPO)] were successfully electrospun into fibers, using ethanol (EtOH) as the spinning solvent. However, electrospinning of these methacrylate-based copolymers and indomethacin (10% by weight of the copolymer) was only successful when an equivolume of EtOH and ethylacetate (EA) was used as the co-solvent system. The drug-loaded as-spun copolymeric fibers appeared to be flat, with the size ranging between 1.2 and 2.5 mu m. At 24 h, the amount of the drug released from these drug-loaded as-spun copolymer fibers was about 55%, 30%, and 18% for drug-loaded as-spun E-EPO, E-L100, and E-RLPO fibers, respectively.
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