期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 57, 期 38, 页码 12463-12467出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201806759
关键词
actively seeking; cell membrane cloak; Janus nanomotor; self-propulsion; thermomechanically perforating
资金
- National Nature Science Foundation of China [21573053]
We report a near-infrared (NIR) light-powered Janus mesoporous silica nanomotor (JMSNM) with macro-phage cell membrane (MPCM) cloaking that can actively seek cancer cells and thermomechanically percolate cell membrane. Upon exposure to NIR light, a heat gradient across the Janus boundary of the JMSNMs is generated by the photothermal effect of the Au half-shells, resulting in a self-thermophoretic force that propels the JMSNMs. In biological medium, the MPCM camouflaging can not only prevent dissociative biological blocks from adhering to JMSNMs but also improve the seeking sensitivity of the nanomotors by specifically recognizing cancer cells. The biofriendly propulsion and recognition capability enable JMSNMs to achieve the active seeking and bind to the membrane of cancer cells. Subsequent illumination with NIR then triggers the photothermal effect of MPCM@JMSNMs to thermomechanically perforate the cytomembranes for guest molecular injection. This approach integrates the functions of active seeking, cytomembranes perforating, and thermomechanical therapy in nanomotors, which may pave the way to apply self-propelled motors in biomedical fields.
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