期刊
CURRENT DRUG TARGETS
卷 8, 期 2, 页码 305-313出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138945007779940115
关键词
chondrocyte; MAP kinase; NF-kappa B; matrix metalloproteinase; protein kinase; protein kinase inhibitor; inflammatory response; osteoarthritis
资金
- Medical Research Council [G8623776] Funding Source: Medline
- MRC [G8623776] Funding Source: UKRI
- Medical Research Council [G8623776] Funding Source: researchfish
Osteoarthritis is characterised by degeneration of articular cartilage. It is thought to be primarily a disease of cartilage. Inflammatory response genes, such as proteinases, cyclooxygenase, and cytokines are implicated in its pathogenesis. The evidence for expression of these genes in articular cartilage in osteoarthritis is reviewed. The expression of inflammatory response genes is controlled by four major intracellular signalling pathways. These lead to activation of the three mitogen-activated protein kinases (MAPK) and the transcriptional regulator nuclear factor kappa (NF kappa)-B. The current state of knowledge of the structure of these pathways is summarized. Pharmacological inhibitors of the protein kinases of the pathways in current use are described, and insights into chondrocyte gene expression obtained with them are discussed. Very limited use of these inhibitors has yet been made in animal models of osteoarthritis.
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