期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 57, 期 40, 页码 13325-13329出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201808555
关键词
arylation; C-C coupling; electrochemistry; oxidation; sulfur heterocycles
资金
- DFG [Wa1276/14-1]
- Carl-Zeiss Foundation
- ELYSION
A novel strategy for the synthesis of biaryls consisting of a benzothiophene and a phenol moiety is reported. These heterobiaryls are of utmost interest for pharmaceutical, biological, and high-performance optoelectronic applications. The metal- and reagent-free, electrosynthetic, and highly efficient method enables the generation of 2- and 3-(hydroxyphenyl)benzo[b]thiophenes in a regioselective fashion. The described one-step synthesis is easy to conduct, scalable, and inherently safe. The products are afforded in high yields of up to 88% and with exquisite selectivity. The reaction also features a broad scope and tolerates a large variety of functional groups.
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