期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 57, 期 43, 页码 14101-14105出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201808074
关键词
photoacoustic imaging; phototheranostics; photothermal therapy; semiconducting polymers; tumor microenvironment
资金
- Youth Innovation Promotion Association of the Chinese Academy of Sciences [2016269]
- Intramural Research Program (IRP) of the NIBIB, NIH
- National Natural Science Foundation of China [81771827, 81471715, 51602203, 51761145021]
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [ZIAEB000073] Funding Source: NIH RePORTER
Tumor-specific phototheranostics is conducive to realizing precise cancer therapy. Herein, a novel tumor microenvironment (TME)-responsive phototheranostic paradigm based on the combination of semiconducting polymer brushes and polyoxometalate clusters (SPB@POM) is rationally designed. The acidic TME could drive the self-assembly of SPB@POM into bigger aggregates for enhanced tumor retention and accumulation, while the reducing TME could significantly enhance the NIR absorption of SPB@POM for significant improvement of photoacoustic imaging contrast and photothermal therapy efficacy. Therefore, the smart pH/glutathione (GSH)-responsive SPB@POM allows for remarkable phototheranostic enhancement under the unique TME, which has potential for precise tumor-specific phototheranostics with minimal side effects.
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