期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 57, 期 46, 页码 15122-15127出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201808908
关键词
biomaterials; hyaluronic acid; hydrogels; photochemistry; sensitizers
资金
- Austrian Science Fund (FWF) [I 2444]
- TU Wien Innovative Projects research funds
Photodegradable hydrogels have emerged as useful platforms for research on cell function, tissue engineering, and cell delivery as their physical and chemical properties can be dynamically controlled by the use of light. The photo-induced degradation of such hydrogel systems is commonly based on the integration of photolabile o-nitrobenzyl derivatives to the hydrogel backbone, because such linkers can be cleaved by means of one-and two-photon absorption. Herein we describe a cytocompatible click-based hydrogel containing o-nitrobenzyl ester linkages between a hyaluronic acid backbone, which is photodegradable in the presence of cells. It is demonstrated for the first time that by using a cyclic benzylidene ketone-based small molecule as photosensitizer the efficiency of the two-photon degradation process can be improved significantly. Biocompatibility of both the improved two-photon micropatterning process as well as the hydrogel itself is confirmed by cell culture studies.
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