期刊
BEHAVIORAL NEUROSCIENCE
卷 121, 期 1, 页码 156-163出版社
AMER PSYCHOLOGICAL ASSOC
DOI: 10.1037/0735-7044.121.1.156
关键词
reconsolidation; cocaine; sensitization; memory
资金
- NIAAA NIH HHS [AA01760] Funding Source: Medline
- NIDA NIH HHS [T32 DA007262] Funding Source: Medline
- NIMH NIH HHS [MH074547] Funding Source: Medline
In experiments examining the potential reconsolidation of drug-associated contextual memories, rats were given a single pairing of cocaine with a specific context, and the ability of the protein synthesis inhibitor anisomycin administered following a context-only memory retrieval trial to impair conditioned locomotor sensitization was tested. Rats receiving 150 mg/kg anisomycin immediately following a 5-min reexposure to the cocaine-conditioned context showed decreased activity compared with the vehicle control group in response to a low-dose cocaine challenge during a subsequent test for conditioned sensitization. This effect was not seen when anisomycin was administered following a 30-min reexposure to the context or when anisomycin was administered 25 min after a 5-min reexposure. These results are consistent with a growing literature suggesting that following retrieval, associative contextual memories may undergo a transient protein synthesis-dependent reconsolidation phase that normally serves to maintain memory.
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