期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 57, 期 47, 页码 15544-15548出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201805908
关键词
conjugation; cycloaddition; fused-ring systems; reaction mechanisms; rhodium
资金
- National Natural Science Foundation of China [21472005]
Reported herein is the first rhodium-catalyzed [4+2+1] cycloaddition of in situ generated ene/yne-ene-allenes and CO to synthesize challenging seven-membered carbo-cycles fused with five-membered rings. This reaction is designed based on the 1,3-acyloxy migration of ene/yne-enepropargyl esters to ene/yne-ene-allenes, followed by oxidative cyclization, CO insertion, and reductive elimination to form the final [4+2+1] cycloadducts. The possible competing [4+1], [4+2], and [2+2+1] cycloadditions were disfavored, making the present reaction an efficient way to access functionalized 5/7 rings.
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