期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 57, 期 37, 页码 12081-12085出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201806295
关键词
aza-Heck reaction; catalysis; dihydroimidazolones; imidazolidinones; palladium
资金
- University of Delaware
- Research Corp. Cottrell Scholars Program
- NIH NIGMS [P20 GM104316]
- NIH [NSF CHE-0421224, CHE-1229234, CHE-1048367, CHE-0840401, P30 GM110758, S10 RR026962, S10 OD016267]
The synthesis of unsaturated, unprotected imidazolidinones via an aza-Heck reaction is described. This palladium-catalyzed process allows for the cyclization of N-phenoxy ureas onto pendant alkenes. The reaction has broad functional group tolerance, can be applied to complex ring topologies, and can be used to directly prepare mono- and bis-unprotected imidazolidinones. By addition of Bu4NI, dihydroimidazolones can be accessed from the same starting materials. Improved conditions for preparing unsaturated, unprotected lactams are also reported.
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