期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 53, 期 12, 页码 3138-3142出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201310589
关键词
block copolymers; crosslinking; permeability; polymersomes; self-assembly
资金
- National Natural Scientific Foundation of China (NNSFC) [21274137, 51273190, 91027026, 51033005]
- Specialized Research Fund for the Doctoral Program of Higher Education (SRFDP) [20123402130010]
The fabrication of block copolymer (BCP) vesicles (polymersomes) exhibiting synchronized covalent crosslinking and bilayer permeabilization remains a considerable challenge as crosslinking typically leads to compromised membrane permeability. Herein it is demonstrated how to solve this dilemma by employing a stimuli-triggered crosslinking strategy with amphiphilic BCPs containing photolabile carbamate-caged primary amines. Upon self-assembling into polymersomes, light-triggered self-immolative decaging reactions release primary amine moieties and extensive amidation reactions then occur due to suppressed amine pK(a) within hydrophobic milieu. This leads to serendipitous vesicle crosslinking and the process is associated with bilayer hydrophobicity-to-hydrophilicity transition and membrane permeabilization.
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