期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 53, 期 7, 页码 1963-1967出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201308899
关键词
antitumor agents; drug design; inflammation; platinum; prodrugs
资金
- Department of Defense Prostate Cancer Idea award [W81XWH-12-1-0406]
Cancer-associated inflammation induces tumor progression to the metastatic stage, thus indicating that a chemo-anti-inflammatory strategy is of interest for the management of aggressive cancers. The platinum(IV) prodrug Platin-A was designed to release cisplatin and aspirin to ameliorate the nephrotoxicity and ototoxicity caused by cisplatin. Platin-A exhibited anticancer and anti-inflammatory properties which are better than a combination of cisplatin and aspirin. These findings highlight the advantages of combining anti-inflammatory treatment with chemotherapy when both the drugs are delivered in the form of a single prodrug.
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