期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 53, 期 32, 页码 8467-8470出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201404570
关键词
asymmetric catalysis; hydrogenation; ion pairs; reaction mechanisms; rhodium
资金
- National Science Foundation [NSF CHE 0956784]
- China Scholarship Council
- National S&T Major Project of China [2012ZX09504001-003]
- National Institutes of Health [NIH R01 GM077437]
Asymmetric hydrogenation of unprotected NH imines catalyzed by rhodium/bis(phosphine)-thiourea provided chiral amines with up to 97% yield and 95% ee. H-1 NMR studies, coupled with control experiments, implied that catalytic chloride-bound intermediates were involved in the mechanism through a dual hydrogen-bonding interaction. Deuteration experiments proved that the hydrogenation proceeded through a pathway consistent with an imine.
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