期刊
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
卷 71, 期 2, 页码 594-597出版社
TAYLOR & FRANCIS LTD
DOI: 10.1271/bbb.60534
关键词
Pz-peptidase; thimet oligopeptidase; neurolysin; phosphine peptide; oligopeptidase
Pz peptidases A and bacillus collagenovorans B, from a thermophile Geo-bacillus recognize collagen-specific tripeptide units (Gly-Pro-Xaa). They share similarities in function but extremely low identities in primary sequence with mammalian thimet oligopeptidase (TOP) and neurolysin. Three phosphine peptide inhibitors that selectively inhibit TOP and neurolysin on two bacterial Pz peptidases were investigated. They showed potent inhibition of both Pz peptidases in a range from 10 to 100 nm.
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