期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 53, 期 6, 页码 1650-1653出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201307484
关键词
alkynes; boron; copper; homogeneous catalysis; synthetic methods
A new and safe method for the synthesis of N-(trifluoromethylthio)phthalimide, a convenient and shelf-stable reagent for the direct trifluoromethylthiolation, has been developed. N-(Trifluoromethylthio)phthalimide can be used as an electrophilic source of F3CS+ and reacts readily with boronic acids and alkynes under copper catalysis. The utility of CF3S-containing molecules as biologically active agents, the mild reaction conditions employed, and the high tolerance of functional groups demonstrate the potential of this new methodology to be widely applied in organic synthesis as well as industrial pharmaceutical and agrochemical research and development.
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